Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG 2 D and inhibits natural killer cell-mediated cytotoxicity

@inproceedings{Cerboni2006HumanIV,
  title={Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG 2 D and inhibits natural killer cell-mediated cytotoxicity},
  author={Cristina Cerboni and Francesca Neri and Nicoletta Casartelli and Alessandra Zingoni and David J. Cosman and Paolo Rossi and Angela Santoni and Margherita Doria},
  year={2006}
}
Received 11 April 2006 Accepted 2 September 2006 Natural killer (NK) cells are a major component of the host innate immune defence against various pathogens. Several viruses, including Human immunodeficiency virus 1 (HIV-1), have developed strategies to evade the NK-cell response. This study was designed to evaluate whether HIV-1 could interfere with the expression of NK cell-activating ligands, specifically the human leukocyte antigen (HLA)-I-like MICA and ULBP molecules that bind NKG2D, an… CONTINUE READING

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