Human immunodeficiency virus, restriction factors, and interferon.

  title={Human immunodeficiency virus, restriction factors, and interferon.},
  author={Stuart J. D. Neil and Paul D Bieniasz},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={29 9},
Recent discoveries have revealed previously unappreciated complexity with which retroviruses interact with their hosts. In particular, we have become aware that many mammals, including humans, are equipped with genes encoding so-called "restriction factors," that provide considerable resistance to retroviral infection. Such antiretroviral genes are sometimes constitutively expressed, and sometimes interferon-induced. Thus they can be viewed as comprising an intrinsic immune system that provides… CONTINUE READING
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