Human immune responses to porcine xenogeneic matrices and their extracellular matrix constituents in vitro.

@article{Bayrak2010HumanIR,
  title={Human immune responses to porcine xenogeneic matrices and their extracellular matrix constituents in vitro.},
  author={Alexandra Bayrak and Maria Tyralla and Juliane Ladhoff and Martina Schleicher and U A Stock and H P Volk and Martina Seifert},
  journal={Biomaterials},
  year={2010},
  volume={31 14},
  pages={3793-803}
}
Several tissue engineering approaches for the treatment of cardiovascular diseases are based on a xenogeneic extracellular matrix. However, the application of engineered heart valves has failed in some patients, causing severe signs of inflammation by so far undetermined processes. Therefore we investigated the immune-mediated responses to porcine valve matrices (native, decellularized and glutaraldehyde-fixed) and to purified xenogeneic extracellular matrix proteins (ECMp). The induction of… CONTINUE READING