Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis.

  title={Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis.},
  author={John R. Black and David W. Dyer and Mareike K. Thompson and P. Frederick Sparling},
  journal={Infection and immunity},
  volume={54 3},
Neisseria meningitidis grown under iron-limiting conditions in vitro expresses additional iron-repressible outer membrane proteins (FeRPs). To see which FeRPs were expressed and immunogenic in human infection, we examined purified membranes from four meningococcal disease isolates with Western blotting of patient sera. Convalescent serum from each patient contained immunoglobulin G (IgG) and IgM antibodies against the homologous 70-kilodalton (kDa) FeRP and IgG antibody to the homologous 94-kDa… CONTINUE READING


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