Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.

@article{Wang2013HumanIO,
  title={Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.},
  author={Su Wang and Janna M Bates and Xiaojie Li and Steven J. Schanz and Devin Chandler-Militello and Corri B. Levine and Nimet Maherali and Lorenz Studer and Konrad Hochedlinger and Martha S. Windrem and Steven A Goldman},
  journal={Cell stem cell},
  year={2013},
  volume={12 2},
  pages={252-64}
}
Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of the congenitally dysmyelinated brain. To establish a potential autologous source of these cells, we developed a strategy by which to differentiate human induced pluripotent stem cells (hiPSCs) into OPCs. From three hiPSC lines, as well as from human embryonic stem cells (hESCs), we generated highly enriched OLIG2(+)/PDGFRα(+)/NKX2.2(+)/SOX10(+) human OPCs, which could be further purified using… CONTINUE READING
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