Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast.

@article{Guillas2003HumanHO,
  title={Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast.},
  author={Isabelle Guillas and James Chengshan Jiang and Christine Vionnet and Carole Roubaty and Dani{\`e}le Uldry and Rachel Chuard and Jinqing Wang and S. Michal Jazwinski and Andreas Conzelmann},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 39},
  pages={
          37083-91
        }
}
Lag1p and Lac1p are two highly homologous membrane proteins of the endoplasmic reticulum. lag1delta lac1delta double mutants in Saccharomyces cerevisiae lack an acyl-CoA-dependent ceramide synthase and are either very sick or nonviable, depending on the genetic background. LAG1 and LAC1 are members of a large eukaryotic gene family that shares the Lag1 motif, and some members of this family additionally contain a DNA-binding HOX homeodomain. Here we show that several human LAG1 homologues can… CONTINUE READING
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