Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.

@article{Karanu2001HumanHO,
  title={Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.},
  author={Frances N. Karanu and Barbara Murdoch and Takao Miyabayashi and Mizuki Ohno and Masahide Koremoto and Lisa M. Gallacher and D Wu and Akifumi Itoh and Seiji Sakano and Mohit Bhatia},
  journal={Blood},
  year={2001},
  volume={97 7},
  pages={1960-7}
}
Delta-mediated Notch signaling controls cell fate decisions during invertebrate and murine development. However, in the human, functional roles for Delta have yet to be described. This study reports the characterization of Delta-1 and Delta-4 in the human. Human Delta-4 was found to be expressed in a wide range of adult and fetal tissues, including sites of hematopoiesis. Subsets of immature hematopoietic cells, along with stromal and endothelial cells that support hematopoiesis, were shown to… CONTINUE READING