Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.

@article{Krietsch2006HumanHO,
  title={Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.},
  author={Tom Krietsch and Maria Sofia Fernandes and Jukka Kero and Ralf Loesel and Maria Heyens and Eric W-F Lam and I lpo Huhtaniemi and Jan Joris Brosens and Birgit Gellersen},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 12},
  pages={3146-64}
}
The steroid hormone progesterone exerts pleiotrophic functions in many cell types. Although progesterone controls transcriptional activation through binding to its nuclear receptors, it also initiates rapid nongenomic signaling events. Recently, three putative membrane progestin receptors (mPRalpha, beta, and gamma) with structural similarity to G protein-coupled receptors have been identified. These mPR isoforms are expressed in a tissue-specific manner and belong to the larger, highly… CONTINUE READING