Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins

Abstract

Notch and the m9/10 gene (groucho) of the Enhancer of split (E(spl)) complex are members of the “Notch group” of genes, which is required for a variety of cell fate choices in Drosophila. We have characterized human cDNA clones encoding a family of proteins, designated TLE, that are homologous to the E(spl) m9/10 gene product, as well as a novel Notch… (More)
DOI: 10.1038/ng1092-119

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