Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.

@article{Tennstaedt2012HumanHT,
  title={Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.},
  author={Annette Tennstaedt and Simon Poepsel and Linda Truebestein and Patrick Hauske and Anke Brockmann and Nina Schmidt and Inga Irle and Barbara Sacc{\`a} and Christof M Niemeyer and Roland Brandt and Hanna Księżak-Reding and Anca Laura Tirniceriu and Rupert Egensperger and Alfonso Baldi and Leif Dehmelt and Markus Kaiser and Robert Huber and Tim Clausen and Michael Ehrmann},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 25},
  pages={20931-41}
}
Protective proteases are key elements of protein quality control pathways that are up-regulated, for example, under various protein folding stresses. These proteases are employed to prevent the accumulation and aggregation of misfolded proteins that can impose severe damage to cells. The high temperature requirement A (HtrA) family of serine proteases has evolved to perform important aspects of ATP-independent protein quality control. So far, however, no HtrA protease is known that degrades… CONTINUE READING

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