Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells.

@article{Ong1994HumanHD,
  title={Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells.},
  author={Albert C. M. Ong and Terry P Jowett and John F. Moorhead and John S. Owen},
  journal={Kidney international},
  year={1994},
  volume={46 5},
  pages={1315-21}
}
The vasoconstrictive and mitogenic actions of endothelins have been implicated in the pathogenesis of progressive renal disease. In the present study, we have assessed whether plasma high density lipoproteins (HDL), the major filtered urinary lipoprotein in nephrotic states, can influence endothelin-1 (ET-1) production by cultured human renal proximal tubular cells. Human HDL was found to stimulate ET-1 secretion up to fourfold in a dose- and time-dependent manner; the effect was greater in… CONTINUE READING

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