Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda.


BACKGROUND Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission. METHODS Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1. RESULTS HHV-8 seroprevalence increased from 16% among children aged 1.5-2 years to 32% among children aged 10-13 years (P <.001) and from 37% among participants aged 14-19 years to 49% among adults aged ≥ 50 years (P <.05). HHV-8 seropositivity in children was independently associated with residing with a seropositive parent (P < .001) and residing with ≥ 1 other seropositive child aged <14 years (P < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (P = .05). Among 1404 participants aged ≥ 15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (P > .10). CONCLUSIONS Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.

DOI: 10.1093/infdis/jiq092

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@article{Butler2011HumanH8, title={Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda.}, author={Lisa M. Butler and Willy A Were and Steven Balinandi and Robert G. Downing and Sheila C. Dollard and Torsten B. Neilands and Sundeep Gupta and George Rutherford and Jonathan Mermin}, journal={The Journal of infectious diseases}, year={2011}, volume={203 5}, pages={625-34} }