Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

@article{Szpakowska2016HumanH8,
  title={Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.},
  author={Martyna Szpakowska and Nadine Dupuis and Alessandra Baragli and Manuel Counson and Julien Hanson and Jacques G Piette and Andy Chevign{\'e}},
  journal={Biochemical pharmacology},
  year={2016},
  volume={114},
  pages={
          14-21
        }
}
The atypical chemokine receptor CXCR7/ACKR3 binds two endogenous chemokines, CXCL12 and CXCL11, and is upregulated in many cancers or following infection by several cancer-inducing viruses, including HHV-8. ACKR3 is a ligand-scavenging receptor and does not activate the canonical G protein pathways but was proposed to trigger β-arrestin-dependent signaling. Here, we identified the human herpesvirus 8-encoded CC chemokine vCCL2/vMIP-II as a third high-affinity ligand for ACKR3. vCCL2 acted as… CONTINUE READING
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