Human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF50 interacts synergistically with the tat gene product in transactivating the human immunodeficiency virus type 1 LTR.

@article{Caselli2001HumanH,
  title={Human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF50 interacts synergistically with the tat gene product in transactivating the human immunodeficiency virus type 1 LTR.},
  author={Elisabetta Caselli and Paola Menegazzi and Arianna Bracci and Monica Amado Galvan and Enzo N. Cassai and Dario Di Luca},
  journal={The Journal of general virology},
  year={2001},
  volume={82 Pt 8},
  pages={
          1965-70
        }
}
Human herpesvirus-8 (HHV-8) is a lymphotropic virus associated with several AIDS-related neoplasms. Two ORFs play a critical role in the regulation of virus replication: ORF50, encoding an immediate-early transcriptional activator, and ORF57, encoding a post-transcriptional regulator. We analysed their effects on the activation of the human immunodeficiency virus type 1 (HIV-1) LTR. ORF50 interacted synergically with tat, inducing a 10-fold enhancement of HIV-1 LTR transactivation. This effect… CONTINUE READING

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