Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46.

@article{Mori2002HumanH6,
  title={Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46.},
  author={Yasuko Mori and Tsukasa Seya and Hong Lan Huang and Pilailuk Akkapaiboon and Panadda Dhepakson and Koichi Yamanishi},
  journal={Journal of virology},
  year={2002},
  volume={76 13},
  pages={6750-61}
}
Human herpesvirus 6 (HHV-6) is a lymphotropic betaherpesvirus that productively infects T cells and monocytes. HHV-6 isolates can be differentiated into two groups, variants A and B (HHV-6A and HHV-6B). Here, we show a functional difference between HHV-6A and -6B in that HHV-6A induced syncytium formation of diverse human cells but HHV-6B did not. The syncytium formation induced by HHV-6A was observed 2 h after infection; moreover, it was found in the presence of cycloheximide, indicating that… CONTINUE READING
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