Human herpesvirus 6 and Epstein-Barr virus in Hodgkin's disease: a controlled study by polymerase chain reaction and in situ hybridization.

@article{Valente1996HumanH6,
  title={Human herpesvirus 6 and Epstein-Barr virus in Hodgkin's disease: a controlled study by polymerase chain reaction and in situ hybridization.},
  author={Guido Valente and Paola Secchiero and Paolo Lusso and Maria Cesarina Abete and Cristina Jemma and Gigliola Reato and S{\"o}nmezoglu Kerim and Robert C. Gallo and Giorgio Palestro},
  journal={The American journal of pathology},
  year={1996},
  volume={149 5},
  pages={1501-10}
}
Human herpesvirus-6 (HHV-6), a T-lymphotropic double-stranded DNA virus highly endemic in human populations, has been suggested to play a possible role in the development of lymphoid neoplasms, especially Hodgkin's disease. To investigate this point, we evaluated the presence and distribution of HHV-6 DNA by Southern blot, nested polymerase chain reaction, and in situ hybridization in a series of lymphoproliferative disorders including 73 Hodgkin's disease cases, 15 non-Hodgkin lymphomas, and… CONTINUE READING

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