Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.

@article{Du2014HumanHW,
  title={Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.},
  author={Yuanyuan Du and Jinlin Wang and Jun Jia and Nan Song and Chengang Xiang and Jun Xu and Z. Hou and Xiaohua Su and Bei Liu and Tao Jiang and Dongxin Zhao and Yingli Sun and Jian Shu and Qingliang Guo and Ming Yin and Da Wen Sun and Shichun Lu and Yan Shi and Hongkui Deng},
  journal={Cell stem cell},
  year={2014},
  volume={14 3},
  pages={394-403}
}
Obtaining fully functional cell types is a major challenge for drug discovery and regenerative medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we show that functional human induced hepatocytes (hiHeps) can be generated from fibroblasts by overexpressing the hepatic fate conversion factors HNF1A, HNF4A, and HNF6 along with the maturation factors ATF5, PROX1, and CEBPA. hiHeps express a spectrum of phase I and II drug-metabolizing enzymes and phase III drug… CONTINUE READING
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