Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

@article{Gmezlechn2004HumanHI,
  title={Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.},
  author={M. Jos{\'e} G{\'o}mez-lech{\'o}n and Mar{\'i}a Teresa Donato and Jose V Castell and Ramiro Jover},
  journal={Current drug metabolism},
  year={2004},
  volume={5 5},
  pages={
          443-62
        }
}
Different types of hepatic tissue, including whole or split livers from organ donors or waste liver from therapeutic liver resections, are used to prepare human hepatocyte cultures. Characteristics of liver samples from different origins (gender, age, healthy/pathological status, xenobiotic treatment) as sources of human hepatocytes are key factors which notably determine viability and functionality of hepatocytes. The characterisation of the CYP system can be assessed in terms of activity… CONTINUE READING
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