Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.

@article{Drewes1996HumanHN,
  title={Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.},
  author={Thomas M. Drewes and Sabine Senkel and Beatrix Holewa and Gerhart U. Ryffel},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 3},
  pages={925-31}
}
Hepatocyte nuclear factor 4 (HNF4) was first identified as a DNA binding activity in rat liver nuclear extracts. Protein purification had then led to the cDNA cloning of rat HNF4, which was found to be an orphan member of the nuclear receptor superfamily. Binding sites for this factor were identified in many tissue-specifically expressed genes, and the protein was found to be essential for early embryonic development in the mouse. We have now isolated cDNAs encoding the human homolog of the rat… CONTINUE READING