Human hepatic stellate cells express class I alcohol dehydrogenase and aldehyde dehydrogenase but not cytochrome P4502E1.

@article{Casini1998HumanHS,
  title={Human hepatic stellate cells express class I alcohol dehydrogenase and aldehyde dehydrogenase but not cytochrome P4502E1.},
  author={A Casini and Giulia Pellegrini and Elisabetta Ceni and Renata Salzano and Maurizio Parola and Gaia Robino and Stefano Milani and Mario Umberto Dianzani and Calogero Surrenti},
  journal={Journal of hepatology},
  year={1998},
  volume={28 1},
  pages={40-5}
}
BACKGROUND/AIMS Alcohol dehydrogenase, cytochrome P4502E1 (CYP2E1), and aldehyde dehydrogenase are known to play an important role in alcohol metabolism in the liver. Although the ethanol oxidation pathways are mainly localized in hepatocytes, we examine whether human hepatic stellate cells might also metabolize ethanol and acetaldehyde. METHODS Hepatic stellate cells were isolated from normal human livers and exposed in vitro to 50 mmol/l ethanol or 85 micromol/l acetaldehyde for different… CONTINUE READING