Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.

  title={Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.},
  author={Robert F. Schwabe and Ram{\'o}n Bataller and David A. Brenner},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={285 5},
Activated hepatic stellate cells (HSCs) are the main producers of extracellular matrix in the fibrotic liver and are involved in the regulation of hepatic inflammation. The aim of this study was to characterize the role of regulated on activation, normal T-cell expressed, and presumably secreted (RANTES) in activated HSCs. RANTES mRNA and protein secretion were strongly induced after stimulating HSCs with TNF-alpha, IL-1beta, or CD40L. RANTES production was NF-kappaB dependent, because… 

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  • G. Ramm
  • Medicine, Biology
  • 2009
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