Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.

  title={Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.},
  author={Lester Bornheim and Jerome M. Lasker and Judy L. Raucy},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={20 2},
Hepatic microsomal metabolism of delta 1-tetrahydrocannabinol (THC) has been extensively studied in many rodent species, but there have been few reports describing such metabolism in humans. Because several THC metabolites are known to be pharmacologically active, identifying the P-450 subfamilies responsible for their formation is of clinical importance. We have found that, in addition to catalyzing the formation of significant amounts of 7-hydroxy-THC, hepatic microsomes from nine human… CONTINUE READING


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