Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.

  title={Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.},
  author={Robert J Foxenberg and Barbara P. McGarrigle and James B Knaak and Paul J. Kostyniak and James R. Olson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={35 2},
Organophosphorus pesticides (OPs) remain a potential concern to human health because of their continuing worldwide use. Thiophosphorus OPs, once bioactivated by cytochromes P450 (P450s), form oxon metabolites, which are potent acetylcholinesterase inhibitors. This study investigated the rate of desulfation (activation) and dearylation (detoxification) of parathion and chlorpyrifos in human liver microsomes. In addition, recombinant human P450s were used to quantify, for the first time, the P450… CONTINUE READING
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