Human hepatic CYP2B6 developmental expression: the impact of age and genotype.

@article{Croom2009HumanHC,
  title={Human hepatic CYP2B6 developmental expression: the impact of age and genotype.},
  author={Edward L Croom and Jeffrey C. Stevens and Ronald N Hines and A. D. Wallace and Ernest Hodgson},
  journal={Biochemical pharmacology},
  year={2009},
  volume={78 2},
  pages={184-90}
}
Although CYP2B6 is known to metabolize numerous pharmaceuticals and toxicants in adults, little is known regarding CYP2B6 ontogeny or its possible role in pediatric drug/toxicant metabolism. To address this knowledge gap, hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank (N=217). Donor ages ranged from 10 weeks gestation to 17 years of age with a median age of 1.9 months. CYP2B6 levels were measured by semi-quantitative… CONTINUE READING