Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury.

@article{Chen2009HumanHS,
  title={Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury.},
  author={Sean W. C. Chen and Sang Won Park and Mihwa Kim and Kevin M Brown and Vivette D D'agati and Heewon Lee},
  journal={Transplantation},
  year={2009},
  volume={87 10},
  pages={1478-87}
}
BACKGROUND Hepatic ischemia reperfusion injury (IRI) is a major clinical problem during the perioperative period and occurs frequently after major hepatic resection or liver transplantation. Our laboratory previously demonstrated that exogenous A1 adenosine receptor activation protects against renal IRI by upregulation and phosphorylation of heat shock protein 27 (HSP27). METHODS This study used mice overexpressing human HSP27 (huHSP27 OE) to determine whether these mice are protected against… CONTINUE READING
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