Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.

@article{Sistonen1994HumanHS,
  title={Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.},
  author={Lea Sistonen and Kevin D. Sarge and Richard I. Morimoto},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 3},
  pages={2087-99}
}
Two members of the heat shock transcription factor (HSF) family, HSF1 and HSF2, both function as transcriptional activators of heat shock gene expression. However, the inducible DNA-binding activities of these two factors are regulated by distinct pathways. HSF1 is activated by heat shock and other forms of stress, whereas HSF2 is activated during hemin-induced differentiation of human K562 erythroleukemia cells, suggesting a role for HSF2 in regulating heat shock gene expression under… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 83 extracted citations

Similar Papers

Loading similar papers…