Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins.

@article{Guilherme1995HumanHT,
  title={Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins.},
  author={Luiza Guilherme and Edecio Cunha-Neto and Ver{\^o}nica Porto Carreiro de Vasconcellos Coelho and Raquel Snitcowsky and Pablo M A Pomerantzeff and Raimunda Violante Campos de Assis and F Pedra and Joachim Neumann and A. I. Goldberg and Manuel Elkin Patarroyo},
  journal={Circulation},
  year={1995},
  volume={92 3},
  pages={415-20}
}
BACKGROUND beta-Hemolytic streptococcal infection in developing countries still causes thousands of causes of rheumatic heart disease, demanding surgical valve correction. Antigenic mimicry between self and streptococcal components has been proposed as the triggering factor leading to autoimmunity in individuals with genetic susceptibility. Although heart streptococcal-M protein cross-reactive antibodies have been demonstrated, heart tissue damage seems to be T lymphocyte-dependent. We studied… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease.

Frontiers in bioscience : a journal and virtual library • 2003
View 4 Excerpts
Highly Influenced

Pathogenesis of group A streptococcal infections.

Clinical microbiology reviews • 2000
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…