Human health effects after exposure to 2,3,7,8-TCDD

  title={Human health effects after exposure to 2,3,7,8-TCDD},
  author={Marie Haring Sweeney and Paolo Mocarelli},
  journal={Food Additives \& Contaminants},
  pages={303 - 316}
In 1949, the first descriptions of human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) contaminated chemicals were reported after a trichlorophenol reactor explosion in Nitro, West Virginia, USA. Reported non-cancer health effects included a range of conditions affecting most systems. Additional reports of the health consequences of exposure continued through the remainder of the century. The majority of effects have been reported among highly exposed groups including… 

Adverse Health Effects in Humans Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)

The environmental contaminant 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) belongs to the category of highly toxic, persistent organic pollutants that accumulate in animal fat and plant tissues and may be causally linked to TCDD only in heavily intoxicated subjects.

Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effect on aryl hydrocarbon receptor expression in a dioxin-resistance model.

The maintenance of relatively constant receptor levels in the face of persistent agonist stimulation is in contrast to the sustained depletion of AHR by TCDD observed in cell culture and to the fluctuations in AHR observed hours to days following acute T CDD exposure in vivo.

Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Hepatic gene downregulation in response to acute and subchronic TCDD exposure is investigated and gender, species, and AhR dependence of these responses were investigated.

Lipid metabolism and neuropsychological follow-up study of workers exposed to 2,3,7,8- tetrachlordibenzo-p-dioxin

Most subjects in the group of 12 former 2,3,7,8-TCDD workers still suffer from disturbances of lipid metabolism, psychic disorders, chloracne, and/or nervous system lesions, and hyperlipidaemia might have played an important role in most of these disorders.

Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

Time independent gene expression signature of the AhR ligands may assist in identifying other agents with the potential to elicit dioxin-like hepatotoxic responses and will help to isolate those genomic responses which are contributing to the hepatotoxicity observed with exposure to DLCs.


The development of the third molar in bank vole was found to be a sensitive biomarker for dioxin exposure, confirming the fact that dioxins are ubiquitous in the environment, also in areas far from contaminant sources and human activity.

2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity

Time course and dose–response analyses of mRNA abundance following TCDD insult indicate that eight genes are similarly regulated in livers of both strains of rat, suggesting that they are not central to the severe L–E-specific T CDD-induced toxicities.

Environmental Chemical-Dioxin Impacts on Biological Systems: A Review

This review briefly review the process, the impacts, and the potential mechanisms of dioxin/dioxin like compound, particularly, their possible roles in adverse developmental and reproductive processes, diseases, and gene expression and associated molecular pathways in cells.



Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

This study of mortality among workers with occupational exposure to TCDD does not confirm the high relative risks reported for many cancers in previous studies, and conclusions about an increase in the risk of soft-tissue sarcoma are limited by small numbers and misclassification on death certificates.

Assessment of past occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin using blood lipid analyses

Estimating cumulative TCDD concentrations back-calculated to the time of exposure for all 254 members of the accident cohort correlated well with chloracne severity and should be helpful in assessing the relationships between various health outcomes.

The Mortality Experience of Workers Exposed to 2,3,7,8‐Tetrachlorodibenzo-p-dioxin in a Trichlorophenol Process Accident

Examination of mortality rates for 754 employees at a chemical plant after an accident in 1949 finds workers exposed to 4-aminobiphenyl who developed chloracne from the accident had increased mortality rates from soft tissue sarcoma, bladder cancer, and respiratory cancer.

Human health effects of 2,4,5-T and its toxic contaminants.

An association was found between the persistence of chloracne and the presence and severity of actinic elastosis of the skin, and there is an association between exposure and the history of gastrointestinal tract ulcer.

Serum dioxin levels in Seveso, Italy, population in 1976.

Assessing human exposure in this potentially exposed population by measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in small volumes of serum specimens remaining from the medical examinations found that the median serum dioxin levels were highest among people who lived closest to the explosion and were progressively lower among groups living farther away, and the serum half-life of dioxIn was 7-8 years, which agrees with other findings.

Mortality of a young population after accidental exposure to 2,3,7,8-tetrachlorodibenzodioxin.

The mortality experience of 19,637 people aged 1-19 years living in an area around Seveso, Italy, contaminated by TCDD after an accidental explosion in a chemical plant was examined, showing a nearly twofold increase in the contaminated area.

Serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy.

Findings are unique in linking clinical histories to TCDD levels following an acute exposure, and yet almost all clinical laboratory tests on these individuals were normal; any abnormal test result was only transitory in nature.

Dioxin exposure and non-malignant health effects: a mortality study.

These results, although not conclusive, concur with previous data in suggesting cardiopulmonary and endocrine effects in humans highly exposed to TCDD, as well as its complex interaction with the endocrine system.

Toxic effects of 2,3,7,8 tetrachlorodibenzo 1,4 dioxin in laboratory workers.

  • R. M. Oliver
  • Medicine
    British journal of industrial medicine
  • 1975
All three scientists were found to have raised serum cholesterol but no other biochemical disturbances, and no porphyrinuria nor liver damage was demonstrated, so it seems likely that these delayed effects were in fact due to dioxin intoxication.