Human gut microbes impact host serum metabolome and insulin sensitivity

@article{Pedersen2016HumanGM,
  title={Human gut microbes impact host serum metabolome and insulin sensitivity},
  author={H. Pedersen and V. Gudmundsdottir and H. Nielsen and T. Hyotylainen and Trine Nielsen and B. Jensen and Kristoffer Forslund and F. Hildebrand and E. Prifti and G. Falony and E. Chatelier and F. Levenez and J. Dor{\'e} and I. Mattila and D. Plichta and P{\"a}ivi P{\"o}h{\"o} and L. Hellgren and Manimozhiyan Arumugam and S. Sunagawa and S. Vieira-Silva and T. J{\o}rgensen and J. Holm and K. Tr{\^o}st and MetaHIT consortium and K. Kristiansen and S. Brix and J. Raes and J. Wang and T. Hansen and P. Bork and S. Brunak and M. Ore{\vs}i{\vc} and S. Ehrlich and O. Pedersen},
  journal={Nature},
  year={2016},
  volume={535},
  pages={376-381}
}
  • H. Pedersen, V. Gudmundsdottir, +31 authors O. Pedersen
  • Published 2016
  • Biology, Medicine
  • Nature
  • Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes… CONTINUE READING
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