Human gut microbes impact host serum metabolome and insulin sensitivity

  title={Human gut microbes impact host serum metabolome and insulin sensitivity},
  author={H. Pedersen and V. Gudmundsdottir and H. Nielsen and T. Hyotylainen and Trine Nielsen and B. Jensen and Kristoffer Forslund and F. Hildebrand and E. Prifti and G. Falony and E. Chatelier and F. Levenez and J. Dor{\'e} and I. Mattila and D. Plichta and P{\"a}ivi P{\"o}h{\"o} and L. Hellgren and Manimozhiyan Arumugam and S. Sunagawa and S. Vieira-Silva and T. J{\o}rgensen and J. Holm and K. Tr{\^o}st and MetaHIT consortium and K. Kristiansen and S. Brix and J. Raes and J. Wang and T. Hansen and P. Bork and S. Brunak and M. Ore{\vs}i{\vc} and S. Ehrlich and O. Pedersen},
  • H. Pedersen, V. Gudmundsdottir, +31 authors O. Pedersen
  • Published 2016
  • Biology, Medicine
  • Nature
  • Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes… CONTINUE READING
    693 Citations

    Paper Mentions

    Observational Clinical Trial
    The accumulation of iron is known to affect the functions of the liver, adipose tissue and muscle. The brain is a well-known place of iron deposition, which is associated with… Expand
    Observational Clinical Trial
    Pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. Recently, however, research on gut microbiome has… Expand
    ConditionsObesity, Childhood
    InterventionDiagnostic Test
    Interventional Clinical Trial
    Aim: To study the effect of a dietary intervention with functional foods on gut microbiota in subjects with type 2 diabetes Materials and methods: Patients with type 2 diabetes were… Expand
    ConditionsType 2 Diabetes Mellitus
    InterventionDietary Supplement
    Metabolites Linking the Gut Microbiome with Risk for Type 2 Diabetes
    • 5
    Role of Gut Microbiome and Microbial Metabolites in Alleviating Insulin Resistance After Bariatric Surgery
    Gut microbial metabolites in obesity, NAFLD and T2DM
    • 200
    • PDF
    Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
    • 375
    • PDF


    The gut microbiota modulates host energy and lipid metabolism in mice[S]
    • 415
    • PDF
    Branched-chain amino acids in metabolic signalling and insulin resistance
    • 540
    Richness of human gut microbiome correlates with metabolic markers
    • 2,297
    • PDF