Human gut microbes impact host serum metabolome and insulin sensitivity

  title={Human gut microbes impact host serum metabolome and insulin sensitivity},
  author={Helle Krogh Pedersen and Valborg Gudmundsdottir and Henrik Bj{\o}rn Nielsen and Tuulia Hyotylainen and Trine Nielsen and Benjamin Anderschou Holbech Jensen and Kristoffer Forslund and Falk Hildebrand and Edi Prifti and Gwen Falony and Emmanuelle Le Chatelier and Florence Levenez and Jo{\"e}l Dor{\'e} and Ismo Mattila and Damian Rafal Plichta and P{\"a}ivi P{\"o}h{\"o} and Lars Ingvar Hellgren and Manimozhiyan Arumugam and Shinichi Sunagawa and Sara Vieira-Silva and Torben J{\o}rgensen and Jacob Bak Holm and Kajetan Tro{\vs}t and MetaHIT consortium and Karsten Kristiansen and Susanne Brix and Jeroen Raes and Jun Wang and Torben Hansen and Peer Bork and S{\o}ren Brunak and Matej Ore{\vs}ič and Stanislav Dusko Ehrlich and Oluf Pedersen},
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes… 
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  • S. Summers
  • Biology, Medicine
    Progress in lipid research
  • 2006