Human growth hormone-releasing hormone hGHRH(1-29)-NH2: systematic structure-activity relationship studies.

@article{Cervini1998HumanGH,
  title={Human growth hormone-releasing hormone hGHRH(1-29)-NH2: systematic structure-activity relationship studies.},
  author={L. Cervini and C. Donaldson and S. Koerber and W. Vale and J. Rivier},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 5},
  pages={
          717-27
        }
}
  • L. Cervini, C. Donaldson, +2 authors J. Rivier
  • Published 1998
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Two complete and two partial structure-activity relationship scans of the active fragment of human growth hormone-releasing hormone, [Nle27]-hGHRH(1-29)-NH2, have identified potent agonists in vitro. Single-point replacement of each amino acid by alanine led to the identification of [Ala8]-, [Ala9]-, [Ala15]- (Felix et al. Peptides 1986 1986, 481), [Ala22]-, and [Ala28, Nle27]-hGHRH(1-29)-NH2 as being 2-6 times more potent than hGHRH(1-40)-OH (standard) in vitro. Nearly complete loss of potency… CONTINUE READING
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