Human growth hormone receptor gene expression is regulated by Gfi-1/1b and GAGA cis-elements.

@article{Kenth2011HumanGH,
  title={Human growth hormone receptor gene expression is regulated by Gfi-1/1b and GAGA cis-elements.},
  author={Gurvinder Kenth and Svetlana Puzhko and Cynthia Gates Goodyer},
  journal={Molecular and cellular endocrinology},
  year={2011},
  volume={335 2},
  pages={135-47}
}
Human growth hormone receptor (hGHR) gene regulation is complex: mRNAs are transcribed from multiple variant (V) 5'UTR exons, several ubiquitously while others only in the postnatal hepatocyte. The liver-specific V1 exon promoter contains Gfi-1/1b repressor sites adjacent to a GAGA box, a GH response element (GHRE) in several mammalian genes. GAGA boxes are… CONTINUE READING