Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors.

@article{Archer1994HumanGH,
  title={Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors.},
  author={Janet Archer and W S Kennan and Michael N. Gould and Robert D. Bremel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 15},
  pages={6840-4}
}
Mammary-specific promoters have been used in transgenic animals to limit transgene expression to the mammary gland. Gene therapy techniques to target just one organ for introduction of a foreign gene have also been demonstrated. We have directly infused replication-defective retroviruses encoding hGH into the mammary gland of goats via the teat canal during a period of hormone-induced mammogenesis. This resulted in the secretion of hGH into the milk when lactation commenced on day 14 of the… CONTINUE READING

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