Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c.

@article{Cockerill1995HumanGC,
  title={Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c.},
  author={Peter N Cockerill and Andrew G. Bert and Father John Jenkins and Gregory Robert Ryan and MichaelO. Shannon and Mathew A. Vadas},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 4},
  pages={
          2071-9
        }
}
The promoter of the human granulocyte-macrophage colony-stimulating factor gene is regulated by an inducible upstream enhancer. The enhancer encompasses three previously defined binding sites for the transcription factor NFAT (GM170, GM330, and GM550) and a novel NFAT site defined here as the GM420 element. While there was considerable redundancy within the enhancer, the GM330, GM420, and GM550 motifs each functioned efficiently in isolation as enhancer elements and bound NFATp and AP-1 in a… CONTINUE READING

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