Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development.

@article{McConnell2011HumanGK,
  title={Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development.},
  author={Sean C. McConnell and Yongliang Huo and Shanrun Liu and Thomas M Ryan},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 4},
  pages={876-83}
}
Elevated levels of fetal γ-globin can cure disorders caused by mutations in the adult β-globin gene. This clinical finding has motivated studies to improve our understanding of hemoglobin switching. Unlike humans, mice do not express a distinct fetal globin. Transgenic mice that contain the human β-globin locus complete their fetal-to-adult hemoglobin switch prior to birth, with human γ-globin predominantly restricted to primitive erythroid cells. We established humanized (100% human hemoglobin… CONTINUE READING