Human globin chain separation by isoelectric focusing.

  title={Human globin chain separation by isoelectric focusing.},
  author={Pier Giorgio Righetti and Elisabetta Gianazza and Alessandro Massimo Gianni and P. Comi and Barb{\'a}ra Giglioni and Sergio Ottolenghi and Camillo Secchi and Luigi Rossi-Bernardi},
  journal={Journal of biochemical and biophysical methods},
  volume={1 1},
Human globin chain separation, a key procedure in the study of hemoglobinopathies, is routinely performed by chromatography on carboxymethylcellulose. This method, though relatively easy and highly reliable, is expensive and time consuming. A new procedure, based on isoelectric focusing, is presented which allows the simultaneous separation of globin chains… CONTINUE READING