Human glioma-associated antigens detected by monoclonal antibodies.

  title={Human glioma-associated antigens detected by monoclonal antibodies.},
  author={J. F. Schnegg and A. C. Diserens and Stefan Carrel and Roberto S. Accolla and Nicolas de Tribolet},
  journal={Cancer research},
  volume={41 3},
Hybridoma cells were derived from a fusion between mouse P3x63/Ag8 myeloma cells and spleen cells from a mouse immunized with whole cells of a human malignant glioma line. Of 345 hybrids obtained, 36 secreted antibodies that reacted with the glioma cell line used for immunization as assayed by an indirect antibody-binding radioimmunoassay. After a first screening for the absence of reactivity on two nongliogenous cell lines, 3 hybrids were selected and cloned by limiting dilution. The… CONTINUE READING


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