Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors.

@article{Mikolajczyk1998HumanGK,
  title={Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors.},
  author={Stephen Dennis Mikolajczyk and Lisa S. Millar and Abhay Kumar and Mohammad Saeed. Saedi},
  journal={The Prostate},
  year={1998},
  volume={34 1},
  pages={
          44-50
        }
}
BACKGROUND Human glandular kallikrein (hK2) is a new potential marker for prostate cancer. It is a serine protease expressed in human prostate epithelial cells which has 78% sequence identity with prostate-specific antigen (PSA). PSA is a widely used biochemical marker for prostate cancer. METHODS Recombinant hK2 expressed in mammalian cells was purified to homogeneity by immunoaffinity chromatography, using an anti-hK2 mAb. hK2 enzymatic specificity was determined on peptide substrates by N… CONTINUE READING
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