Human gingival fibroblasts stress response to HEMA: A role for protein kinase C α.

@article{Cataldi2013HumanGF,
  title={Human gingival fibroblasts stress response to HEMA: A role for protein kinase C α.},
  author={Amelia Cataldi and Susi Zara and Monica Rapino and A Patruno and Viviana di Giacomo},
  journal={Journal of biomedical materials research. Part A},
  year={2013},
  volume={101 2},
  pages={378-84}
}
2-Hydroxyethil methacrylate (HEMA), component of dentin-bonding systems, by diffusing into oral cavity induces a cytotoxic response. HEMA determines reactive oxygen species (ROS) production activating specific signaling pathways, including protein kinases C (PKC). In addition, since a regulation is exerted by various PKCs on nitric oxide synthase (NOS) activation, our aim was to investigate the role of PKCs and the possible interplay with ROS and NO signaling system in human gingival… CONTINUE READING

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