Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression.

@article{Tamai2002HumanGC,
  title={Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression.},
  author={Riyoko Tamai and Tetsuya Sakuta and Kenji Matsushita and Mitsuo Torii and Osamu Takeuchi and Shizuo Akira and Sachiko Akashi and Terje Espevik and Shunji Sugawara and Haruhiko Takada},
  journal={Infection and immunity},
  year={2002},
  volume={70 3},
  pages={1272-8}
}
Gamma interferon (IFN-gamma)-primed human gingival fibroblasts (HGF) have been shown to produce higher levels of interleukin-8 (IL-8) upon stimulation with bacterial products and inflammatory cytokines than nonprimed controls. In this study, we examined whether priming of HGF with IFN-gamma up-regulates IL-8 production by the cells in response to purified lipopolysaccharide (LPS). The priming effect of IFN-gamma was clearly observed in the high-CD14-expressing (CD14(high)) HGF but not in the… CONTINUE READING
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