Human genomic disease variants: a neutral evolutionary explanation.


Many perspectives on the role of evolution in human health include nonempirical assumptions concerning the adaptive evolutionary origins of human diseases. Evolutionary analyses of the increasing wealth of clinical and population genomic data have begun to challenge these presumptions. In order to systematically evaluate such claims, the time has come to… (More)
DOI: 10.1101/gr.133702.111


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@article{Dudley2012HumanGD, title={Human genomic disease variants: a neutral evolutionary explanation.}, author={Joel T. Dudley and Yuseob Kim and Li Liu and Glenn J. Markov and Kristyn Gerold and Rong Chen and Atul J. Butte and Sudhir Kumar}, journal={Genome research}, year={2012}, volume={22 8}, pages={1383-94} }