Human genomic deletions mediated by recombination between Alu elements.

@article{Sen2006HumanGD,
  title={Human genomic deletions mediated by recombination between Alu elements.},
  author={Shurjo K Sen and Kyudong Han and Jianxin Wang and Jungnam Lee and Hui Wang and Pauline Ann Callinan and Matthew Dyer and Richard Cordaux and Ping Liang and Mark A Batzer},
  journal={American journal of human genetics},
  year={2006},
  volume={79 1},
  pages={
          41-53
        }
}
Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage since the human-chimpanzee divergence approximately 6 million years ago. Combining computational data mining and wet-bench experimental verification, we identified 492 human-specific deletions (for a total of approximately 400 kb) attributable to this… CONTINUE READING

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