Human genetics of infectious diseases: a unified theory.

@article{Casanova2007HumanGO,
  title={Human genetics of infectious diseases: a unified theory.},
  author={Jean Casanova and Laurent Abel},
  journal={The EMBO journal},
  year={2007},
  volume={26 4},
  pages={915-22}
}
Since the early 1950s, the dominant paradigm in the human genetics of infectious diseases postulates that rare monogenic immunodeficiencies confer vulnerability to multiple infectious diseases (one gene, multiple infections), whereas common infections are associated with the polygenic inheritance of multiple susceptibility genes (one infection, multiple genes). Recent studies, since 1996 in particular, have challenged this view. A newly recognised group of primary immunodeficiencies… CONTINUE READING
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