Human genetics: Methylation moves into medicine

Abstract

The role of DNA methylation in mammalian development has been a source of controversy for some time. Methylation of DNA, which takes place on the cytosine of CpG dinucleotides, is clearly required for development, because mice lacking the maintenance methyltransferase gene Dnmt1 die early in development [1]. It is also generally agreed that the primary role… (More)
DOI: 10.1016/S0960-9822(00)00286-4

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