Human genetic susceptibility to intracellular pathogens.

  title={Human genetic susceptibility to intracellular pathogens.},
  author={Fredrik Vannberg and S J Chapman and Adrian V S Hill},
  journal={Immunological reviews},
  volume={240 1},
Intracellular pathogens contribute to a significant proportion of infectious disease morbidity and mortality worldwide. Increasing evidence points to a major role for host genetics in explaining inter-individual variation in susceptibility to infectious diseases. A number of monogenic disorders predisposing to infectious disease have been reported, including susceptibility to intracellular pathogens in association with mutations in genes of the interleukin-12/interleukin-23/interferon-γ axis… CONTINUE READING
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