Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature.

@article{Lappegrd2009HumanGD,
  title={Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature.},
  author={Knut Tore Lappeg{\aa}rd and Dorte Bang Christiansen and Anne M Pharo and Ebbe Billmann Thorgersen and Bernt Christian Hellerud and Julie Katrine Lindstad and Erik Waage Nielsen and Grethe Bergseth and Dag J. Fadnes and Tore Gunnar Abrahamsen and Ernst Arne H\oiby and Lone Schejbel and Peter Garred and John D. Lambris and Morten Harboe and Tom Eirik Mollnes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 37},
  pages={15861-6}
}
Complement component C5 is crucial for experimental animal inflammatory tissue damage; however, its involvement in human inflammation is incompletely understood. The responses to gram-negative bacteria were here studied taking advantage of human genetic complement-deficiencies--nature's own knockouts--including a previously undescribed C5 defect. Such deficiencies provide a unique tool for investigating the biological role of proteins. The experimental conditions allowed cross-talk between the… CONTINUE READING

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Role of the complement in experimental sepsis

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