Human genes encoding prothrombin and ceruloplasmin map to 11p11–q12 and 3q21–24, respectively

@article{Royle1987HumanGE,
  title={Human genes encoding prothrombin and ceruloplasmin map to 11p11–q12 and 3q21–24, respectively},
  author={Nicola J Royle and David M. Irwin and Marlys L. Koschinsky and Ross T. A. MacGillivray and John L. Hamerton},
  journal={Somatic Cell and Molecular Genetics},
  year={1987},
  volume={13},
  pages={285-292}
}
The gene for human prothrombin, or factor II (F2) has been assigned to 11p11–q12 by the combined use of a panel of somatic cell hybrid DNAs and in situ hybridization, using both cDNA and genomic probes. In addition, the cDNA probe for F2 recognizes a homologous sequence which has been tentatively mapped to the X chromosome. Similar approaches have been used to confirm the assignment of the ceruloplasmin gene, but to regionally localize it more proximally than previously reported (3q21–q24… Expand
Localization of the gene encoding human factor V to chromosome 1q21-25.
The gene encoding human coagulation Factor V (FV), one of the cofactors in the blood clotting process, has been mapped to chromosome 1 by both Southern hybridization to DNA from human-hamster somaticExpand
Structural gene encoding human factor XII is located at 5q33-qter
The gene encoding human factor XII (F12 ) or Hageman factor has been mapped to 5q33-qter. This has been achieved by analyzing the results obtained from hybridizing a cloned fragment from the factorExpand
Highly polymorphic region of the human prothrombin (F2) gene
TLDR
The sequence differed from that previously reported at as many as 6 positions in a 225-bp stretch spanning exon 6 and its flanking regions; four of these positions were related to endonuclease restriction sites for AluI, HpaII(MspI), MboII, and NcoI. Expand
Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2.
TLDR
A series of overlapping cDNAs coding for mouse prothrombin (coagulation factor II) have been isolated and the composite DNA sequence has been determined and Amino acid residues important for the structure and function of human prothROMbin are conserved in the mouse and bovine proteins. Expand
The pig aminoacylase 1 (ACY1) and ribosomal protein L29 (RPL29)/heparin/heparan sulfate interacting protein (HIP) genes are located together at 13q21→q22, corresponding to human 3p21.1
TLDR
BLAST search results reveal that chromosome 13 contains a transcript similar to human ribosomal protein L29 (RPL29)/heparan sulfate/heparin-interacting protein (HIP) and suggests also that the human RPL29/HIP gene may be near ACY1. Expand
Detection of a new polymorphism of the human prothrombin (F2) gene by combination of PASA and mutated primer-mediated PCR-RFLP
A new polymorphism of the human prothrombin (F2) gene was detected by a combination of polymerase chain reaction (PCR) amplification of specific alleles (PASA) and mutated primer-mediated PCRExpand
Structure of the gene for human coagulation factor V.
TLDR
The isolation and characterization of genomic DNA coding for human factor V is described, which indicates that the protein contains several types of internal repeats with the following domain structure: A1-A2-B-A3-C1-C2. Expand
Isolation and characterization of a processed gene for human ceruloplasmin.
TLDR
The pseudogene that is identified seems to comprise the only sequence in the human genome that is closely related to the wild-type gene, and is mapped to human chromosome 8. Expand
Prothrombin Greenville, Arg517-->Gln, identified in an individual heterozygous for dysprothrombinemia.
TLDR
This is the first report indicating the critical role of Arg517 in the normal physiological interaction of thrombin with fibrinogen, designated Prothrombin Greenville. Expand
A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene.
TLDR
Data strongly support a single origin for factor II G20210A that probably occurred after the divergence of Africans from non-Africans and of Caucasoid from Mongoloid subpopulations. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Characterization, mapping, and expression of the human ceruloplasmin gene.
  • F. Yang, S. Naylor, +7 authors D. Barnett
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
TLDR
The CP gene was mapped to human chromosome 3 by somatic-cell-hybrid analysis and to 3q25 by in situ hybridization; however, sites of hybridization to DNA on other chromosomal sites suggested additional CP-like DNA sequences in the human genome. Expand
The gene for clotting factor 10 is mapped to 13q32----qter.
The structural gene for the human clotting factor 10 (F10) has been mapped to chromosome 13 with a cDNA probe hybridized to DNAs from a panel of human X hamster hybrids. In situ hybridization wasExpand
Regional localization of the human transferrin receptor gene to 3q26.2----qter.
TLDR
The chromosomal locus of the receptor gene was determined by in situ hybridization to 3q26.2----qter, a region of chromosome 3 that appears to be involved in metal transport and that is subject to nonrandom structural rearrangements associated with neoplasia. Expand
Human transferrin: cDNA characterization and chromosomal localization.
  • F. Yang, J. Lum, +5 authors B. Bowman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
Ch Chromosomal mapping by in situ hybridization and somatic cell hybrid analysis indicate that the Tf gene is located at q21-25 on human chromosome 3, consistent with linkage of the T f, Tf receptor, and melanoma p97 loci. Expand
Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).
TLDR
A cDNA clone corresponding to factor IX has been used to detect homologous sequences in the human genome and should be useful for the detection of carriers of the hemophilia B trait and for prenatal diagnosis in informative families and, more generally, for the establishment of a linkage map of the human X chromosome. Expand
Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin.
TLDR
The DNA sequences of a complementary deoxyribonucleic acid (cDNA) and a portion of the gene coding for human prothrombin have been determined and it is proposed that the leader sequence consists of a signal sequence and a pro sequence for the mature protein that circulates in plasma. Expand
Assignment of the haemophilia B (Factor IX) locus to the q26‐qter region of the X chromosome
TLDR
Cloned DNA sequences of the factor IX (Haemophilia B) locus were hybridized to restriction enzyme digests of DNA prepared from a series of somatic cell hybrids containing different X‐chromosomal regions and also in situ to prepared metaphase chromosomes. Expand
Molecular cloning of a cDNA encoding human antihaemophilic factor
TLDR
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed and has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin. Expand
The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA
TLDR
The two independently isolated β-globin clones differ from each other by the presence of a Pst I restriction enzyme cleavage site within the large intervening sequence of the δ- globin gene of one of the clones, which suggests that the human DNA carried in the two clones was derived from two homologous chromosomes which were heterozygous for the PstI restriction enzyme recognition sequence. Expand
High-resolution chromosomal localization of the beta-gene of the human beta-globin gene complex by in situ hybridization.
TLDR
High-resolution chromosome analysis suggests a more precise location of the beta-gene to region 11p15.4---- p15.5 of the human beta-globin gene cluster, as suggested by in situ hybridization. Expand
...
1
2
...