Human gene targeting by viral vectors

@article{Russell1998HumanGT,
  title={Human gene targeting by viral vectors},
  author={David W. Russell and Roll K. Hirata},
  journal={Nature Genetics},
  year={1998},
  volume={18},
  pages={325-330}
}
Stable transduction of mammalian cells typically involves random integration of viral vectors by non-homologous recombination. Here we report that vectors based on adeno-associated virus (AAV) can efficiently modify homologous human chromosomal target sequences. Both integrated neomycin phosphotransferase genes and the hypoxanthine phosphoribosyltransferase gene were targeted by AAV vectors. Site-specific genetic modifications could be introduced into approximately 1% of cells, with the highest… CONTINUE READING
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