Human gene targeting by viral vectors

  title={Human gene targeting by viral vectors},
  author={David W. Russell and Roll K. Hirata},
  journal={Nature Genetics},
Stable transduction of mammalian cells typically involves random integration of viral vectors by non-homologous recombination. Here we report that vectors based on adeno-associated virus (AAV) can efficiently modify homologous human chromosomal target sequences. Both integrated neomycin phosphotransferase genes and the hypoxanthine phosphoribosyltransferase gene were targeted by AAV vectors. Site-specific genetic modifications could be introduced into approximately 1% of cells, with the highest… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
128 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 128 extracted citations

Similar Papers

Loading similar papers…