Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.

@article{Ballabeni2004HumanGP,
  title={Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.},
  author={Andrea Ballabeni and Marina Melixetian and Raffaella Zamponi and Laura Masiero and Federica Marinoni and Kristian Helin},
  journal={The EMBO journal},
  year={2004},
  volume={23 15},
  pages={3122-32}
}
Geminin is an unstable inhibitor of DNA replication that negatively regulates the licensing factor CDT1 and inhibits pre-replicative complex (pre-RC) formation in Xenopus egg extracts. Here we describe a novel function of Geminin. We demonstrate that human Geminin protects CDT1 from proteasome-mediated degradation by inhibiting its ubiquitination. In particular, Geminin ensures basal levels of CDT1 during S phase and its accumulation during mitosis. Consistently, inhibition of Geminin synthesis… CONTINUE READING

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