Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors

  title={Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors},
  author={Dr. A. Pfeiffer and BA C.Hanack and Reinhard Kopp and Reinhold Tacke and U. Moser and PhD E. Mutschler and G{\"u}nter Lambrecht and M. Herawi},
  journal={Digestive Diseases and Sciences},
Five subtypes of muscarinic receptors have been distinguished by pharmacological and molecular biological methods. This report characterizes the muscarinic subtype present in human gastric mucosa by radioligand binding studies. The receptor density was 27 ±6 fmollmg protein and the tritiated ligand N-methylscopolamine had an affinity of (KD)0.39±0.08 nM (n=11). The M1 receptor selective antagonist pirenzepine and the M2 receptor selective ligand AF-DX 116 had low affinities of 148±32 nM (n=13… CONTINUE READING
5 Citations
39 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 39 references

Uber die Differenzierung verschiedener muskarinischer Rezeptortypen in Muskularis und Mukosa des Magens

  • M Herawi
  • Thesis. Ludwig Maximilians Universit~it M~nchen…
  • 1990

Synthese und Eigenschaften des selektiven Antimuskarinikums Sila-Hexocyclium-Methylsulfat

  • R Tacke, H Linoh, K Rafeiner, G Lambrecht, E Mutschler
  • J Organomet Chem 359:159-168,
  • 1989

Similar Papers

Loading similar papers…