Human gamma-thrombin: lack of correlation between a platelet functional response and glycoprotein V hydrolysis.

@article{JandrotPerrus1987HumanGL,
  title={Human gamma-thrombin: lack of correlation between a platelet functional response and glycoprotein V hydrolysis.},
  author={Martine Jandrot-Perrus and Marie Claude Guillin and Paquita Nurden},
  journal={Thrombosis and haemostasis},
  year={1987},
  volume={58 3},
  pages={915-20}
}
The ability of purified human gamma-thrombin to stimulate platelet function was related to its capacity to degrade GP V. Compared to alpha-thrombin, much greater amounts of gamma-thrombin were required to induce platelet aggregation; and this also applied to secretion from dense bodies, alpha-granules and lysosomal granules. Platelet stimulation by gamma-thrombin was additionally characterized by the presence of a lag-phase. Platelets with 3H-labelled surface glycoproteins showed the same… CONTINUE READING